EVOFOSFAMIDE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 8A9RZ3HN8W

Structure
InChI Key UGJWRPJDTDGERK-UHFFFAOYSA-N
Smile Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+](=O)[O-]
InChI
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H16Br2N5O4P
Molecular Weight 449.04
AlogP 1.92
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 111.32
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme
- 301-4838 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Melanoma 2 D008545 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL260046
DrugBank DB06091
EPA CompTox DTXSID60238721
FDA SRS 8A9RZ3HN8W
Guide to Pharmacology 8695
SureChEMBL SCHEMBL2357174
ZINC ZINC000029053729
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