TOLIMIDONE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: MU3JD8E9IS

Structure
InChI Key HJQILFPVRNHTIG-UHFFFAOYSA-N
Smile Cc1cccc(Oc2cnc(O)nc2)c1
InChI
InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H10N2O2
Molecular Weight 202.21
AlogP 2.28
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 55.24
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR Tyrosine-protein kinase Lyn positive allosteric modulator PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
63 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL8030
EPA CompTox DTXSID50194786
FDA SRS MU3JD8E9IS
Guide to Pharmacology 9433
SureChEMBL SCHEMBL21168610
ZINC ZINC000017120697
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