BENAZEPRIL HYDROCHLORIDE

Search structure
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: N1SN99T69T

Structure
InChI Key VPSRQEHTHIMDQM-FKLPMGAJSA-N
Smile CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O.Cl
InChI
InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H29ClN2O5
Molecular Weight 460.96
AlogP 2.57
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 95.94
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Angiotensin-converting enzyme inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 101

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Kidney Diseases 3 D007674 ClinicalTrials
Nephritis, Hereditary 2 D009394 ClinicalTrials
Lecithin Cholesterol Acyltransferase Deficiency 1 D007863 ClinicalTrials
Purpura, Schoenlein-Henoch 1 D011695 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 3012
ChEMBL CHEMBL1694
EPA CompTox DTXSID9045922
FDA SRS N1SN99T69T
KEGG C07701
SureChEMBL SCHEMBL42194
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