DERAZANTINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: N9B0H171MJ

Structure
InChI Key KPJDVVCDVBFRMU-AREMUKBSSA-N
Smile COCCNCCc1cccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccccc2F)C3)c1
InChI
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H29FN4O
Molecular Weight 468.58
AlogP 5.49
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 59.07
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 35.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor inhibitor Other Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cholangiocarcinoma 2 D018281 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Urinary Bladder Neoplasms 1 D001749 ClinicalTrials
Stomach Neoplasms 1 D013274 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297187
DrugBank DB14889
FDA SRS N9B0H171MJ
Guide to Pharmacology 9785
SureChEMBL SCHEMBL13273847
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