LANIFIBRANOR

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 28Q8AG0PYL

Structure
InChI Key OQDQIFQRNZIEEJ-UHFFFAOYSA-N
Smile O=C(O)CCCc1cc2cc(Cl)ccc2n1S(=O)(=O)c1ccc2ncsc2c1
InChI
InChI=1S/C19H15ClN2O4S2/c20-13-4-7-17-12(8-13)9-14(2-1-3-19(23)24)22(17)28(25,26)15-5-6-16-18(10-15)27-11-21-16/h4-11H,1-3H2,(H,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H15ClN2O4S2
Molecular Weight 434.93
AlogP 4.55
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 89.26
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Peroxisome proliferator-activated receptor agonist PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 1.342
Enzyme
- - - - 1.342
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1
1500-3200 - - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 2
866-2962 - - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3
206-4111 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Scleroderma, Diffuse 2 D045743 ClinicalTrials
Non-alcoholic Fatty Liver Disease 2 D065626 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4091374
DrugBank DB14801
FDA SRS 28Q8AG0PYL
PDB BJB
SureChEMBL SCHEMBL3528615
CONTENTS