ENOBOSARM

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: O3571H3R8N

Structure
InChI Key JNGVJMBLXIUVRD-SFHVURJKSA-N
Smile C[C@](O)(COc1ccc(C#N)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1
InChI
InChI=1S/C19H14F3N3O3/c1-18(27,11-28-15-6-2-12(9-23)3-7-15)17(26)25-14-5-4-13(10-24)16(8-14)19(20,21)22/h2-8,27H,11H2,1H3,(H,25,26)/t18-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H14F3N3O3
Molecular Weight 389.33
AlogP 3.22
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 106.14
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Androgen Receptor modulator
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 5.495
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - 1.45-18.84
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- 3-20 - 0.55-38 -25-90

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Muscular Atrophy 3 D009133 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Cachexia 2 D002100 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Urinary Incontinence, Stress 2 D014550 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL1738889
DrugBank DB12078
EPA CompTox DTXSID30233006
FDA SRS O3571H3R8N
PDB RLJ
SureChEMBL SCHEMBL109069
ZINC ZINC000035793636
CONTENTS