| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UKNOWN |
| UNII: | O5CSC6WH1T |
Structure
| InChI Key | AXJQVVLKUYCICH-OAQYLSRUSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H20Cl2N4O2S |
| Molecular Weight | 487.41 |
| AlogP | 4.76 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 74.13 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Cannabinoid CB1 receptor antagonist | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Lipid-like ligand receptor (family A GPCR)
Cannabinoid receptor
|
- | 17-20 | 0-0 | 0-8 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Obesity | 2 | D009765 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 2 | D003924 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL412262 |
| DrugBank | DB12649 |
| FDA SRS | O5CSC6WH1T |
| Guide to Pharmacology | 9234 |
| SureChEMBL | SCHEMBL304252 |
| ZINC | ZINC000003964747 |
CONTENTS