Synonyms: | |
Status: | Approved (2021) |
Entry Type: | Small molecule |
Molecule Category: | UKNOWN |
UNII: | O880NM097T |
InChI Key | PUKBOVABABRILL-YZNIXAGQSA-N |
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Smile | |
InChI |
|
Property Name | Value |
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Molecular Formula | C33H35F4N3O2 |
Molecular Weight | 581.65 |
AlogP | 8.05 |
Hydrogen Bond Acceptor | 3.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 6.0 |
Polar Surface Area | 61.44 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 42.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | C5a anaphylatoxin chemotactic receptor antagonist | PubMed |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 4 | D056648 | ClinicalTrials |
Granulomatosis with Polyangiitis | 4 | D014890 | FDA |
Microscopic Polyangiitis | 4 | D055953 | FDA |
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 4 | D056648 | FDA |
Hidradenitis Suppurativa | 2 | D017497 | ClinicalTrials |
Glomerulonephritis, IGA | 2 | D005922 | ClinicalTrials |
Vasculitis | 2 | D014657 | ClinicalTrials |
Atypical Hemolytic Uremic Syndrome | 2 | D065766 | ClinicalTrials |
Resources | Reference |
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ChEMBL | CHEMBL3989871 |
DrugBank | DB15011 |
FDA SRS | O880NM097T |
Guide to Pharmacology | 9450 |
PDB | EFD |
SureChEMBL | SCHEMBL2567144 |