IZENCITINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 2ZT81PV5UM

Structure
InChI Key DADAEARVGOQWHV-OSYLJGHBSA-N
Smile Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)n2)n[nH]1
InChI
InChI=1S/C22H26N8/c1-14-10-21(29-28-14)26-20-13-19-18(4-2-8-24-19)22(27-20)25-15-11-16-5-6-17(12-15)30(16)9-3-7-23/h2,4,8,10,13,15-17H,3,5-6,9,11-12H2,1H3,(H3,25,26,27,28,29)/t15-,16-,17+

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H26N8
Molecular Weight 402.51
AlogP 3.73
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 105.55
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Janus Kinase (JAK) inhibitor PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Crohn Disease 2 D003424 ClinicalTrials
Colitis, Ulcerative 2 D003093 ClinicalTrials
Inflammatory Bowel Diseases 1 D015212 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4650343
FDA SRS 2ZT81PV5UM
CONTENTS