ONC-201

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 9U35A31JAI

Structure
InChI Key VLULRUCCHYVXOH-UHFFFAOYSA-N
Smile Cc1ccccc1CN1C(=O)C2=C(CCN(Cc3ccccc3)C2)N2CCN=C12
InChI
InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H26N4O
Molecular Weight 386.5
AlogP 3.17
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 39.15
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 29.0

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glioblastoma 2 D005909 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Gliosarcoma 1 D018316 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 1 D000080443 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297310
DrugBank DB14844
FDA SRS 9U35A31JAI
Guide to Pharmacology 9978
SureChEMBL SCHEMBL16227974
ZINC ZINC000169620396
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