NIZATIDINE

Search structure
Synonyms:
Status: Approved (1988)
Entry Type: Small molecule
Molecule Category: Parent
ATC: A02BA04
UNII: P41PML4GHR

Structure
InChI Key SGXXNSQHWDMGGP-UHFFFAOYSA-N
Smile CNC(=C[N+](=O)[O-])NCCSCc1csc(CN(C)C)n1
InChI
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H21N5O2S2
Molecular Weight 331.47
AlogP 1.32
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 83.33
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H2 receptor antagonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gastroesophageal Reflux 4 D005764 ClinicalTrials
Gastroparesis 1 D018589 ClinicalTrials
Gastritis 1 D005756 ClinicalTrials

Cross References

Resources Reference
ChEBI 7601
ChEMBL CHEMBL3183075
DrugBank DB00585
DrugCentral 1955
EPA CompTox DTXSID5023376
FDA SRS P41PML4GHR
SureChEMBL SCHEMBL770
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