FELCISETRAG

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 35F0Y2W16Q

Structure
InChI Key MZOITCJKGUIQEI-UHFFFAOYSA-N
Smile COC(=O)N1CCC(CN2CCC(CNC(=O)c3cccc4[nH]c(C(C)C)nc34)CC2)CC1
InChI
InChI=1S/C25H37N5O3/c1-17(2)23-27-21-6-4-5-20(22(21)28-23)24(31)26-15-18-7-11-29(12-8-18)16-19-9-13-30(14-10-19)25(32)33-3/h4-6,17-19H,7-16H2,1-3H3,(H,26,31)(H,27,28)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H37N5O3
Molecular Weight 455.6
AlogP 3.61
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 90.56
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Serotonin 4 (5-HT4) receptor agonist Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - 100000 -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- - - - 11
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
1-2 - - 0 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Gastroparesis 2 D018589 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL2402904
DrugBank DB12725
FDA SRS 35F0Y2W16Q
Guide to Pharmacology 8426
SureChEMBL SCHEMBL390795
ZINC ZINC000043150989
CONTENTS