TIDEGLUSIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: Q747Y6TT42

Structure
InChI Key PMJIHLSCWIDGMD-UHFFFAOYSA-N
Smile O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
InChI
InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H14N2O2S
Molecular Weight 334.4
AlogP 3.26
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 44.0
Molecular species None
Aromatic Rings 4.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Glycogen synthase kinase-3 beta inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 30.69
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase GSK family
- 5-2000 - - -
Enzyme Protease Cysteine protease
- 600-5900 - - -
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily
- - - - 30.69
Enzyme Transferase
- 80-1550 - - 98.6-101.64
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 992.9 - - 19.25-87.36

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Child Development Disorders, Pervasive 2 D002659 ClinicalTrials
Alzheimer Disease 2 D000544 ClinicalTrials
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Myotonic Dystrophy 2 D009223 ClinicalTrials
Myotonic Dystrophy 2 D009223 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 147398
ChEMBL CHEMBL3545157
DrugBank DB12129
EPA CompTox DTXSID90235682
FDA SRS Q747Y6TT42
Guide to Pharmacology 6929
SureChEMBL SCHEMBL676929
ZINC ZINC000013985228
CONTENTS