LOSARTAN POTASSIUM

Search structure
Synonyms:
Status: Approved (1995)
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 3ST302B24A

Structure
InChI Key OXCMYAYHXIHQOA-UHFFFAOYSA-N
Smile CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[n-]n2)cc1.[K+]
InChI
InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H22ClKN6O
Molecular Weight 461.01
AlogP 4.27
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 8.0
Polar Surface Area 92.51
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Type-1 angiotensin II receptor antagonist DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A
- 13000 - - -
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B
- 13000 - - -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- 2-10 - 9-25 21-74
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 8530 - - -
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 34100 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Proteinuria 4 D011507 ClinicalTrials
Kidney Diseases 4 D007674 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Marfan Syndrome 3 D008382 ClinicalTrials
Hypertrophy, Left Ventricular 3 D017379 ClinicalTrials
Eosinophilic Esophagitis 2 D057765 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Non-alcoholic Fatty Liver Disease 2 D065626 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Pre-Eclampsia 0 D011225 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL995
EPA CompTox DTXSID3044209
FDA SRS 3ST302B24A
SureChEMBL SCHEMBL42079
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