APIXABAN

Search structure


InChI Key	QNZCBYKSOIHPEH-UHFFFAOYSA-N
Smile	COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1
InChI	InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

Action	Mechanism of Action	Reference
INHIBITOR	Coagulation factor X inhibitor	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	210-230	-	0-0	91-98

Mesh Heading	Maximum Phase	Mesh ID	Reference
Venous Thrombosis	4	D020246	ClinicalTrials
Thrombosis	4	D013927	ClinicalTrials
Severe Acute Respiratory Syndrome	3	D045169	ClinicalTrials
Anemia, Sickle Cell	3	D000755	ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma	3	D054198	ClinicalTrials
Aortic Valve Stenosis	3	D001024	ClinicalTrials
Atrial Flutter	3	D001282	ClinicalTrials
Ischemia	3	D007511	ClinicalTrials
Hematoma	3	D006406	ClinicalTrials
Renal Insufficiency	3	D051437	ClinicalTrials
Venous Thromboembolism	3	D054556	ClinicalTrials
Acute Coronary Syndrome	3	D054058	ClinicalTrials
Renal Insufficiency, Chronic	2	D051436	ClinicalTrials
Heart Failure	2	D006333	ClinicalTrials
Takotsubo Cardiomyopathy	2	D054549	ClinicalTrials
Hemorrhage	2	D006470	ClinicalTrials
Foramen Ovale, Patent	2	D054092	ClinicalTrials
Thromboembolism	1	D013923	ClinicalTrials
Ischemic Stroke	1	D000083242	ClinicalTrials
Nephrotic Syndrome	1	D009404	ClinicalTrials
Liver Cirrhosis	1	D008103	ClinicalTrials

CONTENTS


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70