| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UKNOWN |
| UNII: | 40SGR63TGL |
Structure
| InChI Key | VMMKGHQPQIEGSQ-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C9H12N2O7P2 |
| Molecular Weight | 322.15 |
| AlogP | -0.12 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 5.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 152.59 |
| Molecular species | ACID |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 20.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Farnesyl diphosphate synthase inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Transferase
|
- | 2-3 | - | 130 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Osteoporosis | 3 | D010024 | ClinicalTrials |
| Osteoporosis, Postmenopausal | 1 | D015663 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL319144 |
| DrugBank | DB06548 |
| DrugCentral | 4074 |
| EPA CompTox | DTXSID4048779 |
| FDA SRS | 40SGR63TGL |
| Guide to Pharmacology | 3164 |
| PDB | M0N |
| SureChEMBL | SCHEMBL145238 |
| ZINC | ZINC000003803518 |
CONTENTS