ARSENIC TRIOXIDE

Search structure
Synonyms:
Status: Approved (2000)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01XX27
UNII: S7V92P67HO

Structure
InChI Key KTTMEOWBIWLMSE-UHFFFAOYSA-N
Smile O1[As]2O[As]3O[As]1O[As](O2)O3
InChI
InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3

Physicochemical Descriptors

Property Name Value
Molecular Formula As4O6
Molecular Weight 395.68
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Thioredoxin reductase 1 inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 27.08
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Somatostatin receptor
- - 25118.86 - -
Unclassified protein
- - 110000 - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Myelodysplastic Syndromes 3 D009190 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Bronchiolitis Obliterans Syndrome 2 D000092122 ClinicalTrials
Neoplasms, Plasma Cell 2 D054219 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Neuroblastoma 2 D009447 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Urethral Neoplasms 2 D014523 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Ureteral Neoplasms 2 D014516 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Lupus Erythematosus, Systemic 2 D008180 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Gliosarcoma 1 D018316 ClinicalTrials
Thrombocythemia, Essential 1 D013920 ClinicalTrials
Polycythemia Vera 1 D011087 ClinicalTrials
Primary Myelofibrosis 1 D055728 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Acquired Immunodeficiency Syndrome 1 D000163 ClinicalTrials
Central Nervous System Neoplasms 1 D016543 ClinicalTrials
Brain Neoplasms 1 D001932 ClinicalTrials
Primary Myelofibrosis 1 D055728 ClinicalTrials
Carcinoma, Basal Cell 1 D002280 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials

Cross References

Resources Reference
ChEBI 30621
ChEMBL CHEMBL2362016
FDA SRS S7V92P67HO
PubChem 518605
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