TARENFLURBIL

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 501W00OOWA

Structure
InChI Key SYTBZMRGLBWNTM-SNVBAGLBSA-N
Smile C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1
InChI
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H13FO2
Molecular Weight 244.26
AlogP 3.68
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 37.3
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Gamma-secretase modulator PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 1300 - - 0
Enzyme Protease Aspartic protease Aspartic protease AD clan Aspartic protease A22A subfamily Aspartic protease A22A regulatory subfamily
- 100000 - - 23
Enzyme
- 100000 - - 0
Ion channel Other ion channel Miscellaneous ion channel Presenilin ER Ca2+ leak channel family
- 100000 - - 23
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor
- - - - 20

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 3 D000544 ClinicalTrials
Dementia 3 D003704 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 38666
ChEMBL CHEMBL190083
DrugBank DB05289
EPA CompTox DTXSID40199508
FDA SRS 501W00OOWA
Guide to Pharmacology 7340
PDB FLR
SureChEMBL SCHEMBL26131
ZINC ZINC000000008667
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