Synonyms: | |
Status: | Approved (1987) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | C09AA03 |
UNII: | 7Q3P4BS2FD |
InChI Key | RLAWWYSOJDYHDC-BZSNNMDCSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C21H35N3O7 |
Molecular Weight | 441.53 |
AlogP | 1.24 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 12.0 |
Polar Surface Area | 132.96 |
Molecular species | ZWITTERION |
Aromatic Rings | 1.0 |
Heavy Atoms | 29.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Angiotensin-converting enzyme inhibitor | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Protease
Metallo protease
Metallo protease MAE clan
Metallo protease M2 family
|
- | 0-8 | - | 51-132 | 7 | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 5-83 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Heart Failure | 4 | D006333 | FDA |
Myocardial Infarction | 4 | D009203 | FDA |
Hypertrophy, Left Ventricular | 3 | D017379 | ClinicalTrials |
Hyperoxaluria, Primary | 3 | D006960 | ClinicalTrials |
Cardiovascular Diseases | 3 | D002318 | ClinicalTrials |
Diabetes Mellitus | 3 | D003920 | ClinicalTrials |
Diabetic Nephropathies | 3 | D003928 | ClinicalTrials |
Hypertension | 3 | D006973 | ClinicalTrials |
Diabetes Mellitus, Type 2 | 3 | D003924 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Myocardial Infarction | 3 | D009203 | ClinicalTrials |
Atherosclerosis | 3 | D050197 | ClinicalTrials |
Polycystic Kidney Diseases | 3 | D007690 | ClinicalTrials |
Myocardial Ischemia | 3 | D017202 | ClinicalTrials |
Hypercholesterolemia | 3 | D006937 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Coronary Disease | 3 | D003327 | ClinicalTrials |
Non-alcoholic Fatty Liver Disease | 2 | D065626 | ClinicalTrials |
Glomerulosclerosis, Focal Segmental | 2 | D005923 | ClinicalTrials |
Essential Hypertension | 2 | D000075222 | ClinicalTrials |
Lymphoma | 2 | D008223 | ClinicalTrials |
Carcinoma, Hepatocellular | 2 | D006528 | ClinicalTrials |
Lupus Erythematosus, Systemic | 2 | D008180 | ClinicalTrials |
Glomerulonephritis | 2 | D005921 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Azoospermia | 2 | D053713 | ClinicalTrials |
Stroke | 1 | D020521 | ClinicalTrials |
Gastroparesis | 1 | D018589 | ClinicalTrials |
Lecithin Cholesterol Acyltransferase Deficiency | 1 | D007863 | ClinicalTrials |
Vascular Diseases | 1 | D014652 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 43755 |
ChEMBL | CHEMBL1237 |
DrugBank | DB00722 |
DrugCentral | 1587 |
EPA CompTox | DTXSID6040537 |
FDA SRS | 7Q3P4BS2FD |
Human Metabolome Database | HMDB0001938 |
Guide to Pharmacology | 6360 |
PDB | LPR |
PharmGKB | PA450242 |
SureChEMBL | SCHEMBL15680 |
ZINC | ZINC000003812863 |
ChEBI | 6503 |
ChEMBL | CHEMBL419213 |
EPA CompTox | DTXSID2045600 |
FDA SRS | E7199S1YWR |
SureChEMBL | SCHEMBL542591 |