OLOROFIM

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: T34SH2H9HI

Structure
InChI Key SUFPWYYDCOKDLL-UHFFFAOYSA-N
Smile Cc1cc(-c2ccccc2)c(C(=O)C(=O)Nc2ccc(N3CCN(c4ncc(F)cn4)CC3)cc2)n1C
InChI
InChI=1S/C28H27FN6O2/c1-19-16-24(20-6-4-3-5-7-20)25(33(19)2)26(36)27(37)32-22-8-10-23(11-9-22)34-12-14-35(15-13-34)28-30-17-21(29)18-31-28/h3-11,16-18H,12-15H2,1-2H3,(H,32,37)

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H27FN6O2
Molecular Weight 498.56
AlogP 4.08
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 83.36
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Dihydroorotate dehydrogenase (quinone), mitochondrial inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Aspergillosis 3 D001228 ClinicalTrials
Mycoses 2 D009181 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4297609
DrugBank DB15245
FDA SRS T34SH2H9HI
SureChEMBL SCHEMBL17767345
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