DEXRAZOXANE HYDROCHLORIDE

Search structure
Synonyms:
Status: Approved (1995)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 5346058Q7S

Structure
InChI Key BIFMNMPSIYHKDN-FJXQXJEOSA-N
Smile C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1.Cl
InChI
InChI=1S/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H17ClN4O4
Molecular Weight 304.73
AlogP -2.71
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 98.82
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA topoisomerase II inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 19.96

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Breast Neoplasms 4 D001943 ClinicalTrials
Inflammatory Breast Neoplasms 3 D058922 ClinicalTrials
Leukemia, Biphenotypic, Acute 3 D015456 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Ganglioneuroblastoma 3 D018305 ClinicalTrials
Neuroblastoma 3 D009447 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 50224
ChEMBL CHEMBL1200778
EPA CompTox DTXSID60164152
FDA SRS 5346058Q7S
PubChem 24883460
SureChEMBL SCHEMBL18188
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