PCO-371

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: TE53TU0WSQ

Structure
InChI Key LDZJFVOUPUFOHX-UHFFFAOYSA-N
Smile Cc1cc(N2C(=O)NC(=O)C2(C)C)cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(c1ccc(OC(F)(F)F)cc1)NC2=O
InChI
InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44(41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H32F3N5O6S
Molecular Weight 635.67
AlogP 3.32
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 137.48
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 44.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Parathyroid hormone receptor Parathyroid hormone receptor
4100 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypoparathyroidism 1 D007011 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3976807
DrugBank DB14946
FDA SRS TE53TU0WSQ
SureChEMBL SCHEMBL17104864
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