OLORINAB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 581F7DFA9B

Structure
InChI Key ACSQLTBPYZSGBA-GMXVVIOVSA-N
Smile CC(C)(C)[C@@H](CO)NC(=O)c1nn(-c2c[n+]([O-])ccn2)c2c1C[C@@H]1C[C@H]21
InChI
InChI=1S/C18H23N5O3/c1-18(2,3)13(9-24)20-17(25)15-12-7-10-6-11(10)16(12)23(21-15)14-8-22(26)5-4-19-14/h4-5,8,10-11,13,24H,6-7,9H2,1-3H3,(H,20,25)/t10-,11-,13+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H23N5O3
Molecular Weight 357.41
AlogP 0.7
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 4.0
Polar Surface Area 106.98
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Cannabinoid CB2 receptor agonist Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Cannabinoid receptor
6 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Crohn Disease 2 D003424 ClinicalTrials
Irritable Bowel Syndrome 2 D043183 ClinicalTrials
Abdominal Pain 2 D015746 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4175981
DrugBank DB14998
FDA SRS 581F7DFA9B
Guide to Pharmacology 10058
SureChEMBL SCHEMBL11995430
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