TESEVATINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: F6XM2TN5A1

Structure
InChI Key HVXKQKFEHMGHSL-QKDCVEJESA-N
Smile COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1
InChI
InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13-,14-,15+

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H25Cl2FN4O2
Molecular Weight 491.39
AlogP 5.79
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 59.51
Molecular species BASE
Aromatic Rings 3.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Ephrin type-B receptor 4 inhibitor PubMed PubMed Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family
- 0 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 3 D002289 ClinicalTrials
Polycystic Kidney, Autosomal Dominant 2 D016891 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Polycystic Kidney, Autosomal Recessive 1 D017044 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 167674
ChEMBL CHEMBL3544983
DrugBank DB11973
FDA SRS F6XM2TN5A1
SureChEMBL SCHEMBL721993
ZINC ZINC000114456300
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