RUNCACIGUAT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 5EZ01YDT5S

Structure
InChI Key NCRMKIWHFXSBGZ-CNBXIYLPSA-N
Smile C[C@H]([C@H](C(=O)Nc1cc([C@@H](CC(=O)O)C2CC2)ccc1Cl)c1ccc(Cl)cc1)C(F)(F)F
InChI
InChI=1S/C23H22Cl2F3NO3/c1-12(23(26,27)28)21(14-4-7-16(24)8-5-14)22(32)29-19-10-15(6-9-18(19)25)17(11-20(30)31)13-2-3-13/h4-10,12-13,17,21H,2-3,11H2,1H3,(H,29,32)(H,30,31)/t12-,17+,21+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H22Cl2F3NO3
Molecular Weight 488.33
AlogP 6.88
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 8.0
Polar Surface Area 66.4
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
ACTIVATOR Soluble guanylate cyclase activator PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Diabetic Retinopathy 2 D003930 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4650322
FDA SRS 5EZ01YDT5S
CONTENTS