SGS-742

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: GBZ5UC0RME

Structure
InChI Key ONNMDRQRSGKZCN-UHFFFAOYSA-N
Smile CCCCP(=O)(O)CCCN
InChI
InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H18NO2P
Molecular Weight 179.2
AlogP 1.41
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 63.32
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 11.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST GABA-B receptor antagonist PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- - - - 0
Ion channel Ligand-gated ion channel GABA-A receptor
- 62000-62000 - - 0
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor AMPA receptor
- - - - 7
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor Kainate receptor
- - - - 8
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- - - - 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Neurokinin receptor
- - - - 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor
- - - - 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - - 0-0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- - - - 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- - - - 6
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - - 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor
- - - - 0
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) Neurotransmitter receptor (family C GPCR) GABA-B receptor
- 38000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 2 D000544 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL112797
DrugBank DB05010
EPA CompTox DTXSID10154063
FDA SRS GBZ5UC0RME
Guide to Pharmacology 1085
SureChEMBL SCHEMBL195133
ZINC ZINC000026982268
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