NAVOCAFTOR

Search structure


Synonyms:	ABBV-3067 GLPG-3067 GLPG3067
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	W2F2XU189O

Structure


InChI Key	WOXOLLSAICIZNO-UHFFFAOYSA-N
Smile	Nc1cc(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)cnc1-c1nnc(CO)o1
InChI	InChI=1S/C15H11F3N4O5S/c16-15(17,18)27-8-1-3-9(4-2-8)28(24,25)10-5-11(19)13(20-6-10)14-22-21-12(7-23)26-14/h1-6,23H,7,19H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H11F3N4O5S
Molecular Weight	416.34
AlogP	1.94
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	141.43
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Action	Mechanism of Action	Reference
POSITIVE MODULATOR	Cystic fibrosis transmembrane conductance regulator positive modulator

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Other ion channel Chloride channel Cystic fibrosis transmembrane conductance regulator	5.6	-	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference

Cross References

Resources	Reference
ChEMBL	CHEMBL4802150
FDA SRS	W2F2XU189O

CONTENTS