| Synonyms: | |
| Status: | Approved (1981) |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 6E8ZO8LRNM |
Structure
| InChI Key | OHHDIOKRWWOXMT-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C19H23Cl2N5O |
| Molecular Weight | 408.33 |
| AlogP | 2.36 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 45.78 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 26.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Serotonin 2a (5-HT2a) receptor antagonist | FDA |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Surface antigen
|
- | - | 2500 | - | - | |
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 112 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Depressive Disorder | 4 | D003866 | ClinicalTrials |
| Amyotrophic Lateral Sclerosis | 2 | D000690 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 9655 |
| ChEMBL | CHEMBL1200798 |
| EPA CompTox | DTXSID8044626 |
| FDA SRS | 6E8ZO8LRNM |
| SureChEMBL | SCHEMBL61754 |
CONTENTS