FGFR INHIBITOR DEBIO 1347

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: NR9ZYH80Z8

Structure
InChI Key BEMNJULZEQTDJY-UHFFFAOYSA-N
Smile Cc1nc2ccc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)cc2[nH]1
InChI
InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H16N6O
Molecular Weight 356.39
AlogP 3.35
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 3.0
Polar Surface Area 105.38
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor 1 inhibitor PubMed ClinicalTrials
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family
- 22-22 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- 5900 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 2100-2100 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 6900 - - 69

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 2 D009369 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3907479
DrugBank DB12903
FDA SRS NR9ZYH80Z8
Guide to Pharmacology 9787
PDB LWJ
SureChEMBL SCHEMBL10002991
ZINC ZINC000098209140
CONTENTS