TALETRECTINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: W4141180YD

Structure
InChI Key HEVHTYMYEMEBPX-HZPDHXFCSA-N
Smile C[C@@H](N)COc1ccc(-c2cnc3ccc(N[C@H](C)c4cccc(F)c4)nn23)cc1
InChI
InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13,15-16H,14,25H2,1-2H3,(H,27,28)/t15-,16-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H24FN5O
Molecular Weight 405.48
AlogP 4.43
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 77.47
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Neurotrophic tyrosine kinase receptor inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4650989
FDA SRS W4141180YD
PubChem 72202474
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