DANUGLIPRON

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: DN9IUI24GP

Structure
InChI Key HYBAKUMPISVZQP-DEOSSOPVSA-N
Smile N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1
InChI
InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C31H30FN5O4
Molecular Weight 555.61
AlogP 4.89
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 113.5
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 41.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucagon-like peptide 1 receptor agonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C8
- 1250-3340 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 2600-9300 - - 8.4-90
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 2424 - - 86.86
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Glucagon-like receptor Glucagon-like peptide receptor
0.04-12882495.52 - 1.27 80-360 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Liver Diseases 1 D008107 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4518483
FDA SRS DN9IUI24GP
PDB UK4
SureChEMBL SCHEMBL20266351
CONTENTS