| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Unknown |
| Molecule Category: | UNKNOWN |
| UNII: | W0ZE0NT8IF |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H22N8O |
| Molecular Weight | 426.48 |
| AlogP | 2.84 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 139.42 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Adenosine A2a receptor antagonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Nucleotide-like receptor (family A GPCR)
Adenosine receptor
|
- | 31.4 | - | 0.8511-1.5 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
| Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
| Rectal Neoplasms | 2 | D012004 | ClinicalTrials |
| Prostatic Neoplasms, Castration-Resistant | 2 | D064129 | ClinicalTrials |
| Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
| Carcinoma, Pancreatic Ductal | 2 | D021441 | ClinicalTrials |
| Colorectal Neoplasms | 1 | D015179 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4297857 |
| FDA SRS | W0ZE0NT8IF |
CONTENTS