| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Unknown |
| Molecule Category: | UNKNOWN |
| UNII: | 3M2595V4KT |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C29H31F3N6O3 |
| Molecular Weight | 568.6 |
| AlogP | 3.31 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 120.34 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 41.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | C-C chemokine receptor type 2 antagonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Hydrolase
|
- | - | - | - | 0.4581 | |
|
Enzyme
Transferase
|
- | - | - | - | 1.68-18.23 | |
|
Enzyme
|
- | - | - | - | 1.68-18.23 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -48.93-2.23 | |
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 20000 | - | - | 35 | |
|
Membrane receptor
Family A G protein-coupled receptor
Peptide receptor (family A GPCR)
Chemokine receptor
CC chemokine receptor
|
- | 0.5-19 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Hepatitis C, Chronic | 2 | D019698 | ClinicalTrials |
| Osteoarthritis, Knee | 2 | D020370 | ClinicalTrials |
| Carcinoma, Pancreatic Ductal | 2 | D021441 | ClinicalTrials |
| Pancreatic Neoplasms | 1 | D010190 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4650501 |
| FDA SRS | 3M2595V4KT |
CONTENTS