| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | N8VKI8FPW0 |
Structure
| InChI Key | DBSMLQTUDJVICQ-CJODITQLSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H23BrN6O2 |
| Molecular Weight | 483.37 |
| AlogP | 2.82 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 4.0 |
| Number of Rotational Bond | 4.0 |
| Polar Surface Area | 136.1 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Epigenetic regulator
Reader
Methyl-lysine/arginine binding protein
WDR domain
|
- | 0 | - | - | - | |
|
Epigenetic regulator
Writer
Protein methyltransferase
Protein arginine methyltransferase
|
- | 0-6 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Myelodysplastic Syndromes | 1 | D009190 | ClinicalTrials |
| Lymphoma, Non-Hodgkin | 1 | D008228 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4249337 |
| FDA SRS | N8VKI8FPW0 |
| PDB | K8N |
| SureChEMBL | SCHEMBL18572106 |
CONTENTS