BLZ945

Search structure


Synonyms:	Blz945
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	7W3V82OQ0P

Structure


InChI Key	ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Smile	CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1
InChI	InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H22N4O3S
Molecular Weight	398.49
AlogP	3.56
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	96.37
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	1-155	210	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Amyotrophic Lateral Sclerosis	2	D000690	ClinicalTrials
Neoplasms	1	D009369	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL4227505
FDA SRS	7W3V82OQ0P
Guide to Pharmacology	8250
SureChEMBL	SCHEMBL2676695
ZINC	ZINC000068203100

CONTENTS