PF-03049423

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 9CZX3Z9945

Structure
InChI Key MNLNAGRCHNMKKJ-UHFFFAOYSA-N
Smile CCCOCCn1c(=O)c(N2CCN(CCO)CC2)nc2cnc(-c3ccc(OC)nc3)cc21
InChI
InChI=1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H32N6O4
Molecular Weight 468.56
AlogP 1.4
Hydrogen Bond Acceptor 10.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 10.0
Polar Surface Area 105.84
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 34.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- 0-0 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 1790 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Ischemic Stroke 2 D000083242 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL591501
FDA SRS 9CZX3Z9945
SureChEMBL SCHEMBL1969224
ZINC ZINC000045336750
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