ACORAMIDIS

Search structure


Synonyms:	Acoramidis Ag10 AG-10 AG10
Status:	Phase 3
Entry Type:	Small molecule
Molecule Category:	UKNOWN
UNII:	T12B44A1OE

Structure


InChI Key	WBFUHHBPNXWNCC-UHFFFAOYSA-N
Smile	Cc1n[nH]c(C)c1CCCOc1cc(C(=O)O)ccc1F
InChI	InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H17FN2O3
Molecular Weight	292.31
AlogP	2.88
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	75.21
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	21.0

Pharmacology

Action	Mechanism of Action	Reference
STABILISER	Transthyretin stabiliser	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Secreted protein	-	-	5-314	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Amyloid Neuropathies, Familial	3	D028227	ClinicalTrials
Amyloidosis	1	D000686	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3940890
FDA SRS	T12B44A1OE
PDB	16V
SureChEMBL	SCHEMBL15816954
ZINC	ZINC000098207925

CONTENTS