ACORAMIDIS

Search structure
Synonyms:
Status: Approved (2024)
Entry Type: Small molecule
Molecule Category: Free-form
UNII: T12B44A1OE

Structure
InChI Key WBFUHHBPNXWNCC-UHFFFAOYSA-N
Smile Cc1n[nH]c(C)c1CCCOc1cc(C(=O)O)ccc1F
InChI
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H17FN2O3
Molecular Weight 292.31
AlogP 2.88
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 75.21
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
STABILISER Transthyretin stabiliser PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Secreted protein
- - 5-314 - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Amyloid Neuropathies, Familial 3 D028227 ClinicalTrials
Amyloidosis 1 D000686 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3940890
FDA SRS T12B44A1OE
PDB 16V
SureChEMBL SCHEMBL15816954
ZINC ZINC000098207925
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