Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H20N8O2 |
| Molecular Weight | 380.41 |
| AlogP | 1.58 |
| Hydrogen Bond Acceptor | 10.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 104.16 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
Atypical protein kinase group
Atypical protein kinase PIKK family
Atypical protein kinase FRAP subfamily
|
- | 1370 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
Atypical protein kinase group
Atypical protein kinase PIKK family
|
- | 0.6-100 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
Other protein kinase group
Other protein kinase TTK family
|
- | 5011.87-5012 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase PDGFR family
|
- | 3162.28 | - | - | - | |
|
Enzyme
Transferase
|
- | 186.8-14200 | - | - | - | |
|
Enzyme
|
- | 0.6-100 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4650446 |
CONTENTS