Trade Names: | |
Synonyms: | |
Status: | Approved (1961) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | A07EA04 |
UNII: | 9842X06Q6M |
InChI Key | UREBDLICKHMUKA-DVTGEIKXSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H29FO5 |
Molecular Weight | 392.47 |
AlogP | 1.9 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 2.0 |
Polar Surface Area | 94.83 |
Molecular species | NEUTRAL |
Aromatic Rings | 0.0 |
Heavy Atoms | 28.0 |
Primary Target | |
---|---|
Glucocorticoid receptor |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 103 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Pharyngitis | 3 | D010612 | ClinicalTrials |
Premature Birth | 3 | D047928 | ClinicalTrials |
Psoriasis | 3 | D011565 | ClinicalTrials |
Cough | 3 | D003371 | ClinicalTrials |
Pregnancy | 3 | D011247 | ClinicalTrials |
Hypersensitivity | 3 | D006967 | ClinicalTrials |
Carpal Tunnel Syndrome | 3 | D002349 | ClinicalTrials |
Respiratory Distress Syndrome | 3 | D012128 | ClinicalTrials |
Rhinitis, Allergic, Seasonal | 3 | D006255 | ClinicalTrials |
Eczema | 3 | D004485 | ClinicalTrials |
Lichen Planus, Oral | 3 | D017676 | ClinicalTrials |
Psoriasis | 3 | D011565 | ClinicalTrials |
Dry Eye Syndromes | 2 | D015352 | ClinicalTrials |
Glaucoma | 2 | D005901 | ClinicalTrials |
Respiratory Distress Syndrome, Newborn | 2 | D012127 | ClinicalTrials |
Retinal Vein Occlusion | 2 | D012170 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Sciatica | 2 | D012585 | ClinicalTrials |
Bronchiolitis | 2 | D001988 | ClinicalTrials |
Neck Pain | 2 | D019547 | ClinicalTrials |
Macular Edema | 2 | D008269 | ClinicalTrials |
Dermatitis, Atopic | 2 | D003876 | ClinicalTrials |
Tachypnea | 2 | D059246 | ClinicalTrials |
Adenoma | 1 | D000236 | ClinicalTrials |
Hypospadias | 0 | D007021 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 378-44-9 |
ChEBI | 3077 |
ChEMBL | CHEMBL632 |
DrugBank | DB00443 |
DrugCentral | 348 |
EPA CompTox | DTXSID3022667 |
FDA SRS | 9842X06Q6M |
Human Metabolome Database | HMDB0014586 |
Guide to Pharmacology | 7061 |
PharmGKB | PA164754818 |
PubChem | 9782 |
SureChEMBL | SCHEMBL4565 |
ZINC | ZINC000003876136 |