FOSCARNET SODIUM

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Trade Names:
Synonyms:
Status: Approved (1991)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 8C5OQ81LWT
Parent Compound: FOSCARNET

Structure
InChI Key DFHAXXVZCFXGOQ-UHFFFAOYSA-K
Smile O=C([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]
InChI
InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3

Physicochemical Descriptors

Property Name Value
Molecular Formula CNa3O5P
Molecular Weight 191.95
AlogP -0.16
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 1.0
Polar Surface Area 94.83
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 7.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Human herpesvirus 1 DNA polymerase inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 2030-17600 - - -
Enzyme Transferase
- 74000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 111

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cytomegalovirus Retinitis 4 D017726 ClinicalTrials
Digestive System Diseases 3 D004066 ClinicalTrials
Herpes Simplex 3 D006561 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
12.57
Metabolism and nutrition disorders
10.28
Renal and urinary disorders
9.95
General disorders and administration site conditions
8.23
Infections and infestations
8.03
Nervous system disorders
7.39
Blood and lymphatic system disorders
6.34
Investigations
4.73
Respiratory, thoracic and mediastinal disorders
4.69
Vascular disorders
4.6
Gastrointestinal disorders
4.56
Cardiac disorders
3.28
Immune system disorders
2.24
Psychiatric disorders
2.22
Skin and subcutaneous tissue disorders
2.09

Cross References

Resources Reference
ChEBI 141644
ChEMBL CHEMBL754
EPA CompTox DTXSID6023078
FDA SRS 8C5OQ81LWT
KEGG D00579
PubChem 169569
SureChEMBL SCHEMBL7636
ZINC ZINC24629762
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