Trade Names: | |
Synonyms: | |
Status: | Approved (2018) |
Entry Type: | Small molecule |
Molecule Category: | Salt Prodrug |
UNII: | 86EEZ49YVB |
Parent Compound: | FOSTAMATINIB |
InChI Key | ZQGJCHHKJNSPMS-UHFFFAOYSA-L |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H36FN6Na2O15P |
Molecular Weight | 732.52 |
AlogP | 3.09 |
Hydrogen Bond Acceptor | 12.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 10.0 |
Polar Surface Area | 186.72 |
Molecular species | ACID |
Aromatic Rings | 3.0 |
Heavy Atoms | 40.0 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Syk family
|
- | 17 | - | - | - | |
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase VEGFR family
|
- | - | 70 | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Purpura, Thrombocytopenic, Idiopathic | 4 | D016553 | FDA |
Anemia, Hemolytic, Autoimmune | 3 | D000744 | ClinicalTrials |
Lymphoma | 2 | D008223 | ClinicalTrials |
Glomerulonephritis, IGA | 2 | D005922 | ClinicalTrials |
Arthritis, Rheumatoid | 2 | D001172 | ClinicalTrials |
Lupus Erythematosus, Systemic | 2 | D008180 | ClinicalTrials |
Resources | Reference |
---|---|
ChEMBL | CHEMBL3989516 |
FDA SRS | 86EEZ49YVB |
PubChem | 24828759 |
SureChEMBL | SCHEMBL15110498 |