Synonyms: | |
Status: | Approved (2018) |
Entry Type: | Small molecule |
Molecule Category: | Parent Prodrug |
ATC: | B02BX09 |
UNII: | SQ8A3S5101 |
InChI Key | GKDRMWXFWHEQQT-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H26FN6O9P |
Molecular Weight | 580.47 |
AlogP | 3.09 |
Hydrogen Bond Acceptor | 12.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 10.0 |
Polar Surface Area | 186.72 |
Molecular species | ACID |
Aromatic Rings | 3.0 |
Heavy Atoms | 40.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Tyrosine-protein kinase SYK inhibitor | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Syk family
|
- | 17-12000 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Purpura, Thrombocytopenic, Idiopathic | 3 | D016553 | ClinicalTrials |
Arthritis, Rheumatoid | 3 | D001172 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 2 | D045169 | ClinicalTrials |
Glomerulonephritis, IGA | 2 | D005922 | ClinicalTrials |
Anemia, Hemolytic, Autoimmune | 2 | D000744 | ClinicalTrials |
Primary Myelofibrosis | 2 | D055728 | ClinicalTrials |
Lymphoma, Large B-Cell, Diffuse | 2 | D016403 | ClinicalTrials |
Ovarian Neoplasms | 1 | D010051 | ClinicalTrials |
Pneumonia | 1 | D011014 | ClinicalTrials |
Hematologic Neoplasms | 1 | D019337 | ClinicalTrials |
Lymphoma | 1 | D008223 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 901119-35-5 |
ChEMBL | CHEMBL2103830 |
DrugBank | DB12010 |
DrugCentral | 5280 |
FDA SRS | SQ8A3S5101 |
Guide to Pharmacology | 7796 |
PDB | 2RC |
PubChem | 11671467 |
SureChEMBL | SCHEMBL1201371 |
ZINC | ZINC000043131420 |