MECLIZINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1957)
Entry Type: Small molecule
Molecule Category: Salt
UNII: HDP7W44CIO
Parent Compound: MECLIZINE

Structure
InChI Key BAAVORPTHSKWGJ-UHFFFAOYSA-N
Smile Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl.O
InChI
InChI=1S/C25H27ClN2.ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;1H;1H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H31Cl3N2O
Molecular Weight 481.9
AlogP 5.56
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 5.0
Polar Surface Area 6.48
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H1 receptor antagonist PubMed DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
15.84
General disorders and administration site conditions
15.24
Gastrointestinal disorders
9.24
Psychiatric disorders
7.89
Vascular disorders
7.3
Injury, poisoning and procedural complications
5.86
Musculoskeletal and connective tissue disorders
5.36
Immune system disorders
5.16
Cardiac disorders
5.11
Skin and subcutaneous tissue disorders
4.87
Eye disorders
3.97
Respiratory, thoracic and mediastinal disorders
3.77

Cross References

Resources Reference
ChEBI 31805
ChEMBL CHEMBL3989555
FDA SRS HDP7W44CIO
Guide to Pharmacology 2757
KEGG C07116
PubChem 173612
SureChEMBL SCHEMBL743004
ZINC ZINC19594557
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