Trade Names: | |
Synonyms: | |
Status: | Approved (1957) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | D07AA01 |
UNII: | X4W7ZR7023 |
InChI Key | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H30O5 |
Molecular Weight | 374.48 |
AlogP | 1.8 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 2.0 |
Polar Surface Area | 94.83 |
Molecular species | NEUTRAL |
Aromatic Rings | 0.0 |
Heavy Atoms | 27.0 |
Property Name | Value | Unit | Method |
---|---|---|---|
log P (octanol-water) | 1.820 | - | EST |
Atmospheric OH Rate Constant | 7.39E-11 | cm3/molecule-sec | EST |
Melting Point | 232.5 | deg C | EXP |
Water Solubility | 120 | mg/L | EXP |
Primary Target | |
---|---|
Glucocorticoid receptor |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transcription factor
Nuclear receptor
Nuclear hormone receptor subfamily 1
Nuclear hormone receptor subfamily 1 group I
Nuclear hormone receptor subfamily 1 group I member 2
|
12600 | - | - | - | - | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 80 | |
Transporter
Primary active transporter
ATP-binding cassette
ABCB subfamily
|
- | 33030 | - | - | - | |
Transporter
Primary active transporter
ATP-binding cassette
ABCC subfamily
|
- | 40970 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
Multiple Sclerosis, Relapsing-Remitting | 3 | D020529 | ClinicalTrials |
Graft vs Host Disease | 3 | D006086 | ClinicalTrials |
Multiple Sclerosis, Chronic Progressive | 3 | D020528 | ClinicalTrials |
Lupus Erythematosus, Systemic | 3 | D008180 | ClinicalTrials |
Multiple Myeloma | 3 | D009101 | ClinicalTrials |
Respiratory Tract Diseases | 3 | D012140 | ClinicalTrials |
Urinary Tract Infections | 3 | D014552 | ClinicalTrials |
Optic Neuropathy, Ischemic | 3 | D018917 | ClinicalTrials |
Hematologic Neoplasms | 3 | D019337 | ClinicalTrials |
Kidney Diseases | 3 | D007674 | ClinicalTrials |
Purpura, Thrombocytopenic, Idiopathic | 3 | D016553 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials |
Dermatomyositis | 3 | D003882 | ClinicalTrials |
Leukemia | 3 | D007938 | ClinicalTrials |
Lymphoma | 3 | D008223 | ClinicalTrials |
Scleroderma, Systemic | 3 | D012595 | ClinicalTrials |
Heart Diseases | 3 | D006331 | ClinicalTrials |
Renal Insufficiency, Chronic | 3 | D051436 | ClinicalTrials |
Glomerulonephritis, IGA | 3 | D005922 | ClinicalTrials |
Glomerulonephritis, Membranous | 3 | D015433 | ClinicalTrials |
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 3 | D056648 | ClinicalTrials |
Granulomatosis with Polyangiitis | 3 | D014890 | ClinicalTrials |
Lupus Nephritis | 3 | D008181 | ClinicalTrials |
Bell Palsy | 3 | D020330 | ClinicalTrials |
Vestibular Neuronitis | 3 | D020338 | ClinicalTrials |
Respiratory Distress Syndrome | 3 | D012128 | ClinicalTrials |
Microscopic Polyangiitis | 3 | D055953 | ClinicalTrials |
Hematoma, Subdural, Intracranial | 3 | D046648 | ClinicalTrials |
Spinal Cord Injuries | 3 | D013119 | ClinicalTrials |
Thrombocytopenia | 3 | D013921 | ClinicalTrials |
Deglutition Disorders | 3 | D003680 | ClinicalTrials |
Bronchopulmonary Dysplasia | 3 | D001997 | ClinicalTrials |
Edema | 3 | D004487 | ClinicalTrials |
Heart Arrest | 3 | D006323 | ClinicalTrials |
Aging | 3 | D000375 | ClinicalTrials |
Leukemia, Biphenotypic, Acute | 3 | D015456 | ClinicalTrials |
Pulmonary Disease, Chronic Obstructive | 3 | D029424 | ClinicalTrials |
Optic Neuritis | 3 | D009902 | ClinicalTrials |
Pneumonia, Pneumocystis | 3 | D011020 | ClinicalTrials |
Pulpitis | 3 | D011671 | ClinicalTrials |
Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials |
Prostatic Neoplasms, Castration-Resistant | 3 | D064129 | ClinicalTrials |
Graft vs Host Disease | 3 | D006086 | ClinicalTrials |
Lymphohistiocytosis, Hemophagocytic | 3 | D051359 | ClinicalTrials |
Specific Language Disorder | 3 | D000080888 | ClinicalTrials |
Hematologic Neoplasms | 3 | D019337 | ClinicalTrials |
Abdominal Pain | 3 | D015746 | ClinicalTrials |
Ischemic Stroke | 3 | D000083242 | ClinicalTrials |
Hodgkin Disease | 3 | D006689 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
Respiratory Distress Syndrome | 3 | D012128 | ClinicalTrials |
Purpura, Schoenlein-Henoch | 2 | D011695 | ClinicalTrials |
Lymphoma, AIDS-Related | 2 | D016483 | ClinicalTrials |
Neoplasms | 2 | D009369 | ClinicalTrials |
Adenomatous Polyposis Coli | 2 | D011125 | ClinicalTrials |
Hepatitis, Alcoholic | 2 | D006519 | ClinicalTrials |
Melanoma | 2 | D008545 | ClinicalTrials |
Lymphoma, Large-Cell, Anaplastic | 2 | D017728 | ClinicalTrials |
Spasms, Infantile | 2 | D013036 | ClinicalTrials |
Immunoglobulin G4-Related Disease | 2 | D000077733 | ClinicalTrials |
Death, Sudden, Cardiac | 2 | D016757 | ClinicalTrials |
Meniere Disease | 2 | D008575 | ClinicalTrials |
Myeloproliferative Disorders | 2 | D009196 | ClinicalTrials |
Coronavirus Infections | 2 | D018352 | ClinicalTrials |
Lymphoma, Non-Hodgkin | 2 | D008228 | ClinicalTrials |
Appendicitis | 2 | D001064 | ClinicalTrials |
Lymphoproliferative Disorders | 2 | D008232 | ClinicalTrials |
Hantavirus Infections | 2 | D018778 | ClinicalTrials |
Nasal Polyps | 2 | D009298 | ClinicalTrials |
Myelodysplastic-Myeloproliferative Diseases | 2 | D054437 | ClinicalTrials |
Fasciitis, Plantar | 2 | D036981 | ClinicalTrials |
Fallopian Tube Neoplasms | 2 | D005185 | ClinicalTrials |
Radiculopathy | 2 | D011843 | ClinicalTrials |
Anemia, Aplastic | 2 | D000741 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Hyperlipoproteinemia Type I | 2 | D008072 | ClinicalTrials |
Ovarian Neoplasms | 2 | D010051 | ClinicalTrials |
Fanconi Anemia | 2 | D005199 | ClinicalTrials |
Sinusitis | 2 | D012852 | ClinicalTrials |
Spondylarthropathies | 2 | D025242 | ClinicalTrials |
Carpal Tunnel Syndrome | 2 | D002349 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
Spondylitis, Ankylosing | 2 | D013167 | ClinicalTrials |
Pain | 2 | D010146 | ClinicalTrials |
Neuromyelitis Optica | 2 | D009471 | ClinicalTrials |
Myeloproliferative Disorders | 2 | D009196 | ClinicalTrials |
Leukemia, Lymphocytic, Chronic, B-Cell | 2 | D015451 | ClinicalTrials |
Prostatic Neoplasms | 2 | D011471 | ClinicalTrials |
Myelodysplastic Syndromes | 2 | D009190 | ClinicalTrials |
Lymphoma, T-Cell, Peripheral | 2 | D016411 | ClinicalTrials |
Amyotrophic Lateral Sclerosis | 2 | D000690 | ClinicalTrials |
Immunoblastic Lymphadenopathy | 2 | D007119 | ClinicalTrials |
Burkitt Lymphoma | 2 | D002051 | ClinicalTrials |
Neoplasms | 2 | D009369 | ClinicalTrials |
Graves Ophthalmopathy | 2 | D049970 | ClinicalTrials |
Lymphoma, Large B-Cell, Diffuse | 2 | D016403 | ClinicalTrials |
Ovarian Hyperstimulation Syndrome | 1 | D016471 | ClinicalTrials |
Gangliosidoses | 1 | D005733 | ClinicalTrials |
Atherosclerosis | 1 | D050197 | ClinicalTrials |
Muscular Diseases | 1 | D009135 | ClinicalTrials |
Chemical and Drug Induced Liver Injury | 1 | D056486 | ClinicalTrials |
Gaucher Disease | 1 | D005776 | ClinicalTrials |
Stiff-Person Syndrome | 1 | D016750 | ClinicalTrials |
DiGeorge Syndrome | 1 | D004062 | ClinicalTrials |
Mucocutaneous Lymph Node Syndrome | 1 | D009080 | ClinicalTrials |
Frontotemporal Dementia | 1 | D057180 | ClinicalTrials |
Parkinson Disease | 1 | D010300 | ClinicalTrials |
Myasthenia Gravis | 1 | D009157 | ClinicalTrials |
Hearing Loss, Noise-Induced | 1 | D006317 | ClinicalTrials |
Optic Nerve Diseases | 1 | D009901 | ClinicalTrials |
Cognitive Dysfunction | 1 | D060825 | ClinicalTrials |
Immune System Diseases | 1 | D007154 | ClinicalTrials |
Friedreich Ataxia | 0 | D005621 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 83-43-2 |
ChEBI | 6888 |
ChEMBL | CHEMBL650 |
DrugBank | DB00959 |
DrugCentral | 1768 |
EPA CompTox | DTXSID7023300 |
FDA SRS | X4W7ZR7023 |
Human Metabolome Database | HMDB0015094 |
Guide to Pharmacology | 7088 |
PharmGKB | PA450466 |
PubChem | 6741 |
SureChEMBL | SCHEMBL5084 |
ZINC | ZINC000003875560 |