MORPHINE SULFATE

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Trade Names:
Synonyms:
Status: Approved (1984)
Entry Type: Small molecule
Molecule Category: Salt
UNII: X3P646A2J0
Parent Compound: MORPHINE

Structure
InChI Key USAHOPJHPJHUNS-IFCNUISUSA-N
Smile CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O=S(=O)(O)O
InChI
InChI=1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C34H50N2O15S
Molecular Weight 758.84
AlogP 1.2
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 0.0
Polar Surface Area 52.93
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Mu opioid receptor agonist FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Idiopathic Pulmonary Fibrosis 3 D054990 ClinicalTrials
Opioid-Related Disorders 3 D009293 ClinicalTrials
Sleep Apnea, Obstructive 3 D020181 ClinicalTrials
Pruritus 3 D011537 ClinicalTrials
Hypertension, Pulmonary 2 D006976 ClinicalTrials
Neonatal Abstinence Syndrome 2 D009357 ClinicalTrials
Hallux Valgus 2 D006215 ClinicalTrials
Anemia, Sickle Cell 2 D000755 ClinicalTrials
Myocardial Infarction 2 D009203 ClinicalTrials
Osteoarthritis, Knee 2 D020370 ClinicalTrials
Low Back Pain 1 D017116 ClinicalTrials

Related Entries

Scaffolds

Parent
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
16.25
Psychiatric disorders
13.53
Nervous system disorders
11.15
Injury, poisoning and procedural complications
10.33
Immune system disorders
7.77
Gastrointestinal disorders
7.45
Respiratory, thoracic and mediastinal disorders
5.58
Cardiac disorders
3.97
Skin and subcutaneous tissue disorders
3.8
Vascular disorders
3.7
Musculoskeletal and connective tissue disorders
3.35
Investigations
2.9

Cross References

Resources Reference
ChEBI 50731
ChEMBL CHEMBL2103744
EPA CompTox DTXSID1048914
FDA SRS X3P646A2J0
Guide to Pharmacology 1627
KEGG C01516
PDB MOI
PubChem 6321225
SureChEMBL SCHEMBL236214
ZINC ZINC03812983
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