Synonyms: | |
Status: | Approved (1984) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | N02AA01 |
UNII: | 76I7G6D29C |
InChI Key | BQJCRHHNABKAKU-KBQPJGBKSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C17H19NO3 |
Molecular Weight | 285.34 |
AlogP | 1.2 |
Hydrogen Bond Acceptor | 4.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 0.0 |
Polar Surface Area | 52.93 |
Molecular species | BASE |
Aromatic Rings | 1.0 |
Heavy Atoms | 21.0 |
Primary Target | |
---|---|
μ receptor |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | - | - | - | 5 | |
Membrane receptor
Family A G protein-coupled receptor
Peptide receptor (family A GPCR)
Short peptide receptor (family A GPCR)
Opioid receptor
|
4-501 | 4-29300 | - | 0-38 | 61-98 | |
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Monoamine receptor
Adrenergic receptor
|
3 | - | - | - | 25 | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC22 family of organic cation and anion transporters
|
- | 28000-71790 | - | - | 68 | |
Transporter
Primary active transporter
ATP-binding cassette
ABCB subfamily
|
- | - | - | - | 2 | |
Unclassified protein
|
- | - | - | 1427 | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Neoplasms | 3 | D009369 | ClinicalTrials |
Pulmonary Disease, Chronic Obstructive | 3 | D029424 | ClinicalTrials |
Wounds and Injuries | 3 | D014947 | ClinicalTrials |
Neoplasms | 3 | D009369 | ClinicalTrials |
Fractures, Bone | 3 | D050723 | ClinicalTrials |
Neonatal Abstinence Syndrome | 3 | D009357 | ClinicalTrials |
Pruritus | 3 | D011537 | ClinicalTrials |
Opioid-Related Disorders | 3 | D009293 | ClinicalTrials |
Renal Colic | 3 | D056844 | ClinicalTrials |
Sleep Apnea, Obstructive | 3 | D020181 | ClinicalTrials |
Scoliosis | 3 | D012600 | ClinicalTrials |
Obesity | 3 | D009765 | ClinicalTrials |
Pregnancy | 3 | D011247 | ClinicalTrials |
Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
Back Pain | 3 | D001416 | ClinicalTrials |
Anemia, Sickle Cell | 3 | D000755 | ClinicalTrials |
Dyspnea | 3 | D004417 | ClinicalTrials |
Prostatic Neoplasms, Castration-Resistant | 3 | D064129 | ClinicalTrials |
Kidney Calculi | 3 | D007669 | ClinicalTrials |
Opioid-Related Disorders | 3 | D009293 | ClinicalTrials |
Myocardial Infarction | 3 | D009203 | ClinicalTrials |
Rotator Cuff Injuries | 2 | D000070636 | ClinicalTrials |
Hemorrhage | 2 | D006470 | ClinicalTrials |
Fractures, Multiple | 2 | D000069076 | ClinicalTrials |
Blood Coagulation Disorders | 2 | D001778 | ClinicalTrials |
Tonsillitis | 2 | D014069 | ClinicalTrials |
Chronic Pain | 2 | D059350 | ClinicalTrials |
Respiratory Insufficiency | 2 | D012131 | ClinicalTrials |
Neuralgia | 2 | D009437 | ClinicalTrials |
Mucositis | 2 | D052016 | ClinicalTrials |
Postoperative Complications | 2 | D011183 | ClinicalTrials |
Stomatitis | 2 | D013280 | ClinicalTrials |
Premature Birth | 2 | D047928 | ClinicalTrials |
Restless Legs Syndrome | 1 | D012148 | ClinicalTrials |
Rheumatic Diseases | 1 | D012216 | ClinicalTrials |
Constipation | 1 | D003248 | ClinicalTrials |
Heart Arrest | 1 | D006323 | ClinicalTrials |
Heroin Dependence | 1 | D006556 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 57-27-2 |
ChEBI | 17303 |
ChEMBL | CHEMBL70 |
DrugBank | DB00295 |
DrugCentral | 1845 |
EPA CompTox | DTXSID9023336 |
FDA SRS | 76I7G6D29C |
Human Metabolome Database | HMDB0014440 |
Guide to Pharmacology | 1627 |
KEGG | C01516 |
PDB | MOI |
PharmGKB | PA450550 |
PubChem | 5288826 |
SureChEMBL | SCHEMBL2997 |
ZINC | ZINC000003812983 |