LORCASERIN

Search structure
Synonyms:
Status: Approved (2012)
Entry Type: Small molecule
Molecule Category: Parent
ATC: A08AA11
UNII: 637E494O0Z

Structure
InChI Key XTTZERNUQAFMOF-QMMMGPOBSA-N
Smile C[C@H]1CNCCc2ccc(Cl)cc21
InChI
InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H14ClN
Molecular Weight 195.69
AlogP 2.59
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 0.0
Polar Surface Area 12.03
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Primary Target
5-HT2C receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
2-210 - - 15-257 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- - - 2606 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Obesity 4 D009765 ClinicalTrials
Opioid-Related Disorders 2 D009293 ClinicalTrials
Peripheral Nervous System Diseases 2 D010523 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Liver Diseases 1 D008107 ClinicalTrials
Substance-Related Disorders 1 D019966 ClinicalTrials
Marijuana Abuse 1 D002189 ClinicalTrials
Cardiovascular Diseases 1 D002318 ClinicalTrials

Related Entries

Salt

Cross References

Resources Reference
CAS NUMBER 616202-92-7
ChEBI 65353
ChEMBL CHEMBL360328
DrugBank DB04871
DrugCentral 4374
EPA CompTox DTXSID3048659
FDA SRS 637E494O0Z
Guide to Pharmacology 2941
PubChem 11658860
SureChEMBL SCHEMBL169382
ZINC ZINC000006733300
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