NAPHAZOLINE

Search structure
Synonyms:
Status: Approved (1971)
Entry Type: Small molecule
Molecule Category: Parent
ATC: R01AA08
UNII: H231GF11BV

Structure
InChI Key CNIIGCLFLJGOGP-UHFFFAOYSA-N
Smile c1ccc2c(CC3=NCCN3)cccc2c1
InChI
InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H14N2
Molecular Weight 210.28
AlogP 2.38
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 24.39
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 16.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
63-63 410 - 2 -
Other cytosolic protein
- - - 122-122 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Conjunctivitis, Allergic 3 D003233 ClinicalTrials
Common Cold 3 D003139 ClinicalTrials
Influenza, Human 3 D007251 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 835-31-4
ChEBI 93363
ChEMBL CHEMBL761
DrugBank DB06711
DrugCentral 3369
EPA CompTox DTXSID3048449
FDA SRS H231GF11BV
Human Metabolome Database HMDB0015656
Guide to Pharmacology 5509
PharmGKB PA165958384
PubChem 4436
SureChEMBL SCHEMBL34532
ZINC ZINC000000119717
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