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Total: 1496
Protein
Approved
OTHER
INJECTION
Unknown
Insulin receptor agonist
Small molecule
Approved
OTHER
ORAL
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Kidney Calculi; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Heart Failure; Hypertension; Toxemia
Thiazide-sensitive sodium-chloride cotransporter inhibitor
Small molecule
Approved
OTHER
TOPICAL; VAGINAL
Unknown
Cytochrome P450 51 inhibitor
Small molecule
Approved
OTHER
INJECTION; ORAL
Neoplasms, Neuroepithelial; Fallopian Tube Neoplasms; Graft vs Host Disease; Hematologic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Plasma Cell; Lymphoma, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Peritoneal Neoplasms; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Astrocytoma; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Castleman Disease; Glioblastoma; Glioma; Gliosarcoma; Hematologic Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Neuromyelitis Optica; Neutropenia; Oligodendroglioma; Opsoclonus-Myoclonus Syndrome; Optic Nerve Glioma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Severe Acute Respiratory Syndrome; Stiff-Person Syndrome; Thymoma; Waldenstrom Macroglobulinemia; Adenocarcinoma of Lung; Adrenal Cortex Neoplasms; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Embryonal; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Choriocarcinoma; Choroid Plexus Neoplasms; Colorectal Neoplasms; Endodermal Sinus Tumor; Ependymoma; Ganglioneuroblastoma; Gestational Trophoblastic Disease; Granuloma, Lethal Midline; Hepatoblastoma; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Medulloblastoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Osteosarcoma; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Sarcoma, Myeloid; Seminoma; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thymus Neoplasms; Wilms Tumor; Neoplasms
DNA topoisomerase II inhibitor
Small molecule
Approved
OTHER
ORAL
Irritable Bowel Syndrome; Paraplegia; Xanthomatosis, Cerebrotendinous
Bile acid receptor FXR agonist
Small molecule
Approved
OTHER
INJECTION
Osteomyelitis; Endophthalmitis; Appendicitis; Pneumonia; Bacterial Infections; Eye Infections
Unknown
Small molecule
Approved
OTHER
INJECTION; ORAL
Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Seizures; Child Development Disorders, Pervasive; Hypokalemic Periodic Paralysis; Renal Insufficiency, Chronic; Autistic Disorder; Cardiovascular Diseases; Heart Failure; Kidney Diseases; Nephrotic Syndrome
Sodium-(potassium)-chloride cotransporter 2 inhibitor
Small molecule
Approved
OTHER
INHALATION
Unknown
Beta-2 adrenergic receptor agonist
Small molecule
Approved
OTHER
INHALATION
Unknown
Beta-2 adrenergic receptor agonist
Small molecule
Approved
OTHER
INJECTION
Unknown
Phosphodiesterase 3A inhibitor
Small molecule
Approved
OTHER
ORAL
Peripheral Nerve Injuries; Clostridium Infections; Crohn Disease; Colonic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus; Hepatitis C; Hepatitis C, Chronic; Constipation
Osmotic laxative
Small molecule
Approved
OTHER
ORAL
Amyotrophic Lateral Sclerosis; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Psychotic Disorders; Tics; Tourette Syndrome
Dopamine receptor antagonist
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Atherosclerosis; Renal Insufficiency, Chronic; Diabetes Mellitus; Diabetes Mellitus, Type 2
Sulfonylurea receptor 1, Kir6.2 blocker
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; HEMATOLOGY; OTHER
ORAL
Angina, Stable; Ischemic Stroke; Spinal Cord Injuries; Brain Injuries; Diabetes Mellitus, Type 1; Stroke; Diabetes, Gestational; Diabetes Mellitus; Diabetes Mellitus, Type 2
Sulfonylurea receptor 1, Kir6.2 blocker
Unknown
Approved
OTHER
INJECTION
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Prostatic Neoplasms; Adrenal Gland Diseases
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor
Small molecule
Approved
OTHER
INJECTION
Bacterial Infections
Bacterial penicillin-binding protein inhibitor
Small molecule
Approved
OTHER
INJECTION
Bacterial Infections
Bacterial penicillin-binding protein 2 inhibitor
Small molecule
Approved
OTHER
NASAL; ORAL; TRANSDERMAL
Aging; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Memory Disorders; Sarcoidosis; Schizophrenia; Alcohol Drinking; Carcinoma in Situ; Cognitive Dysfunction; Depressive Disorder; Parkinson Disease; Postoperative Nausea and Vomiting; Sarcoma; Substance-Related Disorders; Wounds and Injuries; Heart Failure; Lung Neoplasms; Marijuana Abuse; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Smoking Cessation; Tuberculosis; Uterine Cervical Neoplasms; Tobacco Use Disorder
Neuronal acetylcholine receptor; alpha4/beta2 agonist
Small molecule
Approved
CARDIOVASCULAR; OTHER
ORAL
Anemia; Bipolar Disorder; Crohn Disease; Infertility; Pancreatitis; Central Nervous System Neoplasms; Hepatopulmonary Syndrome; HIV Infections; Muscular Dystrophy, Duchenne; Schizophrenia; Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Acute Kidney Injury; Behcet Syndrome; Biliary Atresia; Brain Diseases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Depressive Disorder, Major; Diabetic Nephropathies; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fatty Liver; Fibrosis; Head and Neck Neoplasms; Leishmaniasis; Leishmaniasis, Cutaneous; Liver Cirrhosis, Biliary; Malaria, Falciparum; Neoplasms; Non-alcoholic Fatty Liver Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoidosis, Pulmonary; Wounds and Injuries; Brachial Plexus Neuropathies; Endometriosis; Glomerulonephritis; Hepatitis, Alcoholic; Liver Cirrhosis; Liver Failure; Neonatal Sepsis; Nephrotic Syndrome; Osteonecrosis; Renal Insufficiency, Chronic; Cardiovascular Diseases
3',5'-cyclic phosphodiesterase inhibitor
Small molecule
Approved
OTHER
TOPICAL
Unknown
Unknown
Small molecule
Approved
OTHER
INJECTION; ORAL; RECTAL; URETHRAL
Breast Neoplasms; Fabry Disease; HIV Infections; Renal Insufficiency; Acute Kidney Injury; Kidney Diseases; Myocardial Ischemia
Diagnostic agent
Small molecule
Approved
OTHER
INJECTION
Carcinoma, Renal Cell; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Breast Neoplasms; Glioma; Pituitary Neoplasms
Diagnostic agent
Protein
Approved
OTHER
INJECTION
Diabetes Mellitus
Insulin receptor agonist
Protein
Approved
OTHER
INJECTION
Hyperglycemia; Atherosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Hypercholesterolemia; Hypertension
Insulin receptor agonist
Small molecule
Approved
OTHER
OPHTHALMIC
Rheumatic Diseases
Cyclooxygenase inhibitor
Small molecule
Approved
OTHER
BILIARY; PERFUSION
Unknown
Unknown
Small molecule
Approved
OTHER
TOPICAL
Tinea Pedis
Cytochrome P450 51 inhibitor
Small molecule
Approved
GASTROINTESTINAL; IMMUNE SYSTEM; OTHER
INHALATION; ORAL
Breast Neoplasms; Neoplasms; Diabetes Mellitus, Type 1; Encephalitis, Japanese; Hemorrhagic Fever with Renal Syndrome; Hepatitis D; Influenza, Human; Lassa Fever; Leukemia, Myeloid, Acute; Thrombocytopenia; Depressive Disorder; Hepatitis; Hepatitis B, Chronic; Hepatitis C; HIV Infections; Infections; Respiratory Syncytial Virus Infections; Severe Acute Respiratory Syndrome; Fibrosis; Hepatitis C, Chronic; Liver Cirrhosis; Virus Diseases
Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor
Small molecule
Approved
OTHER
ORAL
Adenocarcinoma of Lung; Amebiasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Glioblastoma; HIV Infections; Small Cell Lung Carcinoma; Leukemia, Lymphocytic, Chronic, B-Cell; Ovarian Neoplasms; Pain; Tuberculosis; Arthritis, Rheumatoid; Rheumatic Diseases
Unknown
Protein
Approved
OTHER
INJECTION
Unknown
Growth hormone receptor agonist
Small molecule
Approved
OTHER
ORAL
Sleep Initiation and Maintenance Disorders
GABA-A receptor; anion channel positive allosteric modulator
Small molecule
Approved
OTHER
ORAL
Obsessive-Compulsive Disorder; Fibromyalgia; Marijuana Abuse; Muscle Spasticity; Neuralgia; Obesity; Suicidal Ideation; Diabetic Neuropathies; Parkinson Disease; Nausea; Neoplasms; Postoperative Nausea and Vomiting
Cannabinoid CB1 receptor agonist
Small molecule
Approved
OTHER
INJECTION
Osteomyelitis; Cystic Fibrosis; Esophageal Achalasia; Meningitis, Bacterial; Enterobacteriaceae Infections; Skin Diseases; Staphylococcal Skin Infections; Bacterial Infections; Infections; Intraabdominal Infections; Parametritis; Peritonitis; Pneumonia; Pyelonephritis; Urinary Tract Infections
Bacterial penicillin-binding protein inhibitor