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Therapeutic Area
CANCER (51)
CARDIOVASCULAR (45)
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DIABETES DRUGS & ENDOCRINOLOGY (61)
EMERGENCY MEDICINE (3)
ENT (5)
EYE (23)
GASTROINTESTINAL (29)
HEMATOLOGY (23)
MUSCULOSKELETAL (28)
NEUROLOGY DRUGS & NERVOUS SYSTEM (50)
PEDIATRICS (27)
PHARMACOLOGY (8)
PREGNANCY AND GYNECOLOGY (30)
RESPIRATORY (42)
RHEUMATOLOGY (19)
OTHER (1482)
Therapeutic Indication
Adverse Reaction (System Organ Classification)
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Level 1
Level 2
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Level 5
Level 6
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Drug type
Therapeutic Area
Route of administration
Mechanism of Action
Indication
Status
Total:
10647
MECLOCYCLINE SULFOSALICYLATE
1982
Small molecule
Approved
OTHER
TOPICAL
Stomatitis
Bacterial 70S ribosome inhibitor
MECLOCYCLINE SULFOSALICYLATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
46VZA7RX2B
Molecule Type:
Small molecule
Molecular Formula:
C29H27ClN2O14S
Molecular Weight:
695.06
AlogP:
None
PSA:
None
HBD:
None
HBA:
#RotB:
None
Source:
ETOMIDATE
1982
Small molecule
Approved
OTHER
INJECTION
Respiratory Insufficiency; Hypertension; Stroke
GABA-A receptor; anion channel positive modulator
ETOMIDATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
Z22628B598
Molecule Type:
Small molecule
Molecular Formula:
C14H16N2O2
Molecular Weight:
244.29
AlogP:
2.67
PSA:
44.12
HBD:
0.0
HBA:
#RotB:
4.0
Source:
PHENYL AMINOSALICYLATE
1982
Small molecule
Approved
OTHER
ORAL
Unknown
Unknown
PHENYL AMINOSALICYLATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
52936SIP7V
Molecule Type:
Small molecule
Molecular Formula:
C13H11NO3
Molecular Weight:
229.24
AlogP:
2.19
PSA:
72.55
HBD:
2.0
HBA:
#RotB:
2.0
Source:
DIFLUNISAL
1982
Small molecule
Approved
OTHER
ORAL
Amyloid Neuropathies, Familial; Diabetes Mellitus, Type 2; Arthritis, Rheumatoid; Fever; Osteoarthritis; Pain
Cyclooxygenase inhibitor
DIFLUNISAL
×
Maximum Phase:
4
First Approval:
1982
UNII:
7C546U4DEN
Molecule Type:
Small molecule
Molecular Formula:
C13H8F2O3
Molecular Weight:
250.2
AlogP:
3.04
PSA:
57.53
HBD:
2.0
HBA:
#RotB:
2.0
Source:
LAPYRIUM CHLORIDE
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
LAPYRIUM CHLORIDE
×
Maximum Phase:
4
First Approval:
1982
UNII:
732T8851QH
Molecule Type:
Small molecule
Molecular Formula:
C21H35ClN2O3
Molecular Weight:
398.98
AlogP:
3.55
PSA:
59.28
HBD:
1.0
HBA:
#RotB:
15.0
Source:
DIPHENYLPYRALINE
1982
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
DIPHENYLPYRALINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
33361OE3AV
Molecule Type:
Small molecule
Molecular Formula:
C19H23NO
Molecular Weight:
281.4
AlogP:
3.89
PSA:
12.47
HBD:
0.0
HBA:
#RotB:
4.0
Source:
HEXOCYCLIUM
1982
Small molecule
Approved
Unknown
Unknown
Digestive System Diseases
Unknown
HEXOCYCLIUM
×
Maximum Phase:
4
First Approval:
1982
UNII:
LL3147PI1T
Molecule Type:
Small molecule
Molecular Formula:
C20H33N2O+
Molecular Weight:
317.5
AlogP:
2.85
PSA:
23.47
HBD:
1.0
HBA:
#RotB:
4.0
Source:
THIOPENTAL
1982
Small molecule
Approved
Unknown
Unknown
Strabismus; Brain Injuries; Shock, Septic; Status Epilepticus
Unknown
THIOPENTAL
×
Maximum Phase:
4
First Approval:
1982
UNII:
JI8Z5M7NA3
Molecule Type:
Small molecule
Molecular Formula:
C11H18N2O2S
Molecular Weight:
242.34
AlogP:
1.35
PSA:
58.2
HBD:
2.0
HBA:
#RotB:
4.0
Source:
CHLOROTRIANISENE
1982
Small molecule
Approved
OTHER
ORAL
Liver Neoplasms; Carcinoma, Hepatocellular
Estrogen receptor beta modulator
CHLOROTRIANISENE
×
Maximum Phase:
4
First Approval:
1982
UNII:
6V5034L121
Molecule Type:
Small molecule
Molecular Formula:
C23H21ClO3
Molecular Weight:
380.87
AlogP:
5.87
PSA:
27.69
HBD:
0.0
HBA:
#RotB:
6.0
Source:
CERULETIDE DIETHYLAMINE
1982
Protein
Approved
OTHER
INJECTION
Unknown
Cholecystokinin A receptor agonist
CERULETIDE DIETHYLAMINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
4E1MIA8QQL
Molecule Type:
Protein
Molecular Formula:
C62H84N14O21S2
Molecular Weight:
1425.57
AlogP:
None
PSA:
None
HBD:
None
HBA:
#RotB:
None
Source:
VERATRUM VIRIDE ROOT
1982
Small molecule
Approved
OTHER
ORAL
Hypertension
Unknown
VERATRUM VIRIDE ROOT
×
Maximum Phase:
4
First Approval:
1982
UNII:
197B3Q7T5Q
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
THEOPHYLLINE SODIUM GLYCINATE
1982
Small molecule
Approved
OTHER
ORAL
Unknown
Adenosine receptor antagonist
THEOPHYLLINE SODIUM GLYCINATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
2S36N8T753
Molecule Type:
Small molecule
Molecular Formula:
C9H12N5NaO4
Molecular Weight:
277.22
AlogP:
None
PSA:
None
HBD:
None
HBA:
#RotB:
None
Source:
BUCLIZINE
1982
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
BUCLIZINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
0C94V6X681
Molecule Type:
Small molecule
Molecular Formula:
C28H33ClN2
Molecular Weight:
433.04
AlogP:
6.54
PSA:
6.48
HBD:
0.0
HBA:
#RotB:
5.0
Source:
CARBENICILLIN
1982
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Bacterial Infections
Unknown
CARBENICILLIN
×
Maximum Phase:
4
First Approval:
1982
UNII:
G42ZU72N5G
Molecule Type:
Small molecule
Molecular Formula:
C17H18N2O6S
Molecular Weight:
378.41
AlogP:
0.49
PSA:
124.01
HBD:
3.0
HBA:
#RotB:
5.0
Source:
TRICLOFOS
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
TRICLOFOS
×
Maximum Phase:
4
First Approval:
1982
UNII:
J712EO9048
Molecule Type:
Small molecule
Molecular Formula:
C2H4Cl3O4P
Molecular Weight:
229.38
AlogP:
1.47
PSA:
66.76
HBD:
2.0
HBA:
#RotB:
2.0
Source:
OXYPHENONIUM BROMIDE
1982
Small molecule
Approved
OTHER
ORAL
Unknown
Muscarinic acetylcholine receptor M1 antagonist
OXYPHENONIUM BROMIDE
×
Maximum Phase:
4
First Approval:
1982
UNII:
S9421HWB3Z
Molecule Type:
Small molecule
Molecular Formula:
C21H34BrNO3
Molecular Weight:
428.41
AlogP:
3.48
PSA:
46.53
HBD:
1.0
HBA:
#RotB:
8.0
Source:
CLIOQUINOL
1982
Small molecule
Approved
Unknown
Unknown
Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Eczema
Copper chelating agent
CLIOQUINOL
×
Maximum Phase:
4
First Approval:
1982
UNII:
7BHQ856EJ5
Molecule Type:
Small molecule
Molecular Formula:
C9H5ClINO
Molecular Weight:
305.5
AlogP:
3.2
PSA:
33.12
HBD:
1.0
HBA:
#RotB:
0.0
Source:
ACRISORCIN
1982
Small molecule
Approved
OTHER
TOPICAL
Unknown
Unknown
ACRISORCIN
×
Maximum Phase:
4
First Approval:
1982
UNII:
2U918O4BEV
Molecule Type:
Small molecule
Molecular Formula:
C25H28N2O2
Molecular Weight:
388.51
AlogP:
None
PSA:
None
HBD:
None
HBA:
#RotB:
None
Source:
PRAZEPAM
1982
Small molecule
Approved
OTHER
ORAL
Anxiety
GABA-A receptor; anion channel positive allosteric modulator
PRAZEPAM
×
Maximum Phase:
4
First Approval:
1982
UNII:
Q30VCC064M
Molecule Type:
Small molecule
Molecular Formula:
C19H17ClN2O
Molecular Weight:
324.81
AlogP:
3.93
PSA:
32.67
HBD:
0.0
HBA:
#RotB:
3.0
Source:
DIPHENYLPYRALINE HYDROCHLORIDE
1982
Small molecule
Approved
OTHER
ORAL
Unknown
Histamine H1 receptor antagonist
DIPHENYLPYRALINE HYDROCHLORIDE
×
Maximum Phase:
4
First Approval:
1982
UNII:
G9FU7F1E87
Molecule Type:
Small molecule
Molecular Formula:
C19H24ClNO
Molecular Weight:
317.86
AlogP:
3.89
PSA:
12.47
HBD:
0.0
HBA:
#RotB:
4.0
Source:
CHLORAMPHENICOL PALMITATE
1982
Small molecule
Approved
Unknown
Unknown
Acne Vulgaris; Bacterial Infections; Eye Infections
Bacterial 70S ribosome inhibitor
CHLORAMPHENICOL PALMITATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
43VU4207NW
Molecule Type:
Small molecule
Molecular Formula:
C27H42Cl2N2O6
Molecular Weight:
561.55
AlogP:
6.94
PSA:
118.77
HBD:
2.0
HBA:
#RotB:
21.0
Source:
METHYLPROMAZINE
1982
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
METHYLPROMAZINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
76H78MJJ52
Molecule Type:
Small molecule
Molecular Formula:
C18H22N2S
Molecular Weight:
298.45
AlogP:
4.49
PSA:
6.48
HBD:
0.0
HBA:
#RotB:
4.0
Source:
PENTOLINIUM
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
PENTOLINIUM
×
Maximum Phase:
4
First Approval:
1982
UNII:
ULL76WPU5X
Molecule Type:
Small molecule
Molecular Formula:
C15H32N2+2
Molecular Weight:
240.44
AlogP:
2.64
PSA:
0.0
HBD:
0.0
HBA:
#RotB:
6.0
Source:
LEVALLORPHAN
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
LEVALLORPHAN
×
Maximum Phase:
4
First Approval:
1982
UNII:
353613BU4U
Molecule Type:
Small molecule
Molecular Formula:
C19H25NO
Molecular Weight:
283.41
AlogP:
3.64
PSA:
23.47
HBD:
1.0
HBA:
#RotB:
2.0
Source:
CLIDINIUM
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
CLIDINIUM
×
Maximum Phase:
4
First Approval:
1982
UNII:
BO76JF850N
Molecule Type:
Small molecule
Molecular Formula:
C22H26NO3+
Molecular Weight:
352.45
AlogP:
2.7
PSA:
46.53
HBD:
1.0
HBA:
#RotB:
4.0
Source:
METHARBITAL
1982
Small molecule
Approved
OTHER
ORAL
Epilepsy
GABA-A receptor; anion channel positive allosteric modulator
METHARBITAL
×
Maximum Phase:
4
First Approval:
1982
UNII:
02OS7K758T
Molecule Type:
Small molecule
Molecular Formula:
C9H14N2O3
Molecular Weight:
198.22
AlogP:
0.5
PSA:
66.48
HBD:
1.0
HBA:
#RotB:
2.0
Source:
DIPHEMANIL
1982
Small molecule
Approved
Unknown
Unknown
Digestive System Diseases
Unknown
DIPHEMANIL
×
Maximum Phase:
4
First Approval:
1982
UNII:
Q26TX1UD0W
Molecule Type:
Small molecule
Molecular Formula:
C20H24N+
Molecular Weight:
278.42
AlogP:
4.36
PSA:
0.0
HBD:
0.0
HBA:
#RotB:
2.0
Source:
CYCLIZINE
1982
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
CYCLIZINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
QRW9FCR9P2
Molecule Type:
Small molecule
Molecular Formula:
C18H22N2
Molecular Weight:
266.39
AlogP:
3.02
PSA:
6.48
HBD:
0.0
HBA:
#RotB:
3.0
Source:
SULFAMERAZINE
1982
Small molecule
Approved
Unknown
Unknown
Bacterial Infections
Bacterial dihydropteroate synthase inhibitor
SULFAMERAZINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
UR1SAB295F
Molecule Type:
Small molecule
Molecular Formula:
C11H12N4O2S
Molecular Weight:
264.31
AlogP:
1.17
PSA:
97.97
HBD:
2.0
HBA:
#RotB:
3.0
Source:
SULFAPHENAZOLE
1982
Small molecule
Approved
OTHER
ORAL
Bacterial Infections; Eye Infections
Bacterial dihydropteroate synthase inhibitor
SULFAPHENAZOLE
×
Maximum Phase:
4
First Approval:
1982
UNII:
0J8L4V3F81
Molecule Type:
Small molecule
Molecular Formula:
C15H14N4O2S
Molecular Weight:
314.37
AlogP:
2.26
PSA:
90.01
HBD:
2.0
HBA:
#RotB:
4.0
Source:
FLUPREDNISOLONE
1982
Small molecule
Approved
OTHER
ORAL
Unknown
Glucocorticoid receptor agonist
FLUPREDNISOLONE
×
Maximum Phase:
4
First Approval:
1982
UNII:
9H05937G3X
Molecule Type:
Small molecule
Molecular Formula:
C21H27FO5
Molecular Weight:
378.44
AlogP:
1.51
PSA:
94.83
HBD:
3.0
HBA:
#RotB:
2.0
Source:
LEVOMEPROMAZINE
1982
Small molecule
Approved
OTHER
INJECTION
Anxiety; Dementia; Depressive Disorder; Schizophrenia; Psychotic Disorders
D2-like dopamine receptor antagonist
LEVOMEPROMAZINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
9G0LAW7ATQ
Molecule Type:
Small molecule
Molecular Formula:
C19H24N2OS
Molecular Weight:
328.48
AlogP:
4.5
PSA:
15.71
HBD:
0.0
HBA:
#RotB:
5.0
Source:
XENON XE 127
1982
Small molecule
Approved
Unknown
Unknown
Unknown
Diagnostic agent
XENON XE 127
×
Maximum Phase:
4
First Approval:
1982
UNII:
H95KBR1GDB
Molecule Type:
Small molecule
Molecular Formula:
Xe
Molecular Weight:
126.91
AlogP:
None
PSA:
None
HBD:
None
HBA:
#RotB:
None
Source:
QUINIDINE POLYGALACTURONATE
1982
Small molecule
Approved
OTHER
ORAL
Arrhythmias, Cardiac
Sodium channel alpha subunit blocker
QUINIDINE POLYGALACTURONATE
×
Maximum Phase:
4
First Approval:
1982
UNII:
H0C54E9D68
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
GALLAMINE
1982
Small molecule
Unknown
Unknown
Unknown
Unknown
Unknown
GALLAMINE
×
Maximum Phase:
4
First Approval:
1982
UNII:
VYJ027LZ05
Molecule Type:
Small molecule
Molecular Formula:
C30H60N3O3+3
Molecular Weight:
510.83
AlogP:
5.45
PSA:
27.69
HBD:
0.0
HBA:
#RotB:
21.0
Source:
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ALogP
PSA